DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Kawasaki disease. The EFO term mucocutaneous lymph node syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: mucocutaneous lymph node syndrome

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-09-27

SPECIES:

AUTHORS:

YC Lee, HC Kuo, JS Chang, LY Chang, LM Huang, MR Chen, CD Liang, H Chi, FY Huang, ML Lee, YC Huang, B Hwang, NC Chiu, KP Hwang, PC Lee, LC Chang, YM Liu, YJ Chen, CH Chen, YT Chen, FJ Tsai, JY Wu

TITLE:

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.

JOURNAL:

Nature genetics Mar 2012, Vol 44, pp. 522-5

ABSTRACT:

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. PUBMED: 22446961
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