DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body height

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DF Gudbjartsson, GB Walters, G Thorleifsson, H Stefansson, BV Halldorsson, P Zusmanovich, P Sulem, S Thorlacius, A Gylfason, S Steinberg, A Helgadottir, A Ingason, V Steinthorsdottir, EJ Olafsdottir, GH Olafsdottir, T Jonsson, K Borch-Johnsen, T Hansen, G Andersen, T Jorgensen, O Pedersen, KK Aben, JA Witjes, DW Swinkels, M den Heijer, B Franke, AL Verbeek, DM Becker, LR Yanek, LC Becker, L Tryggvadottir, T Rafnar, J Gulcher, LA Kiemeney, A Kong, U Thorsteinsdottir, K Stefansson

TITLE:

Many sequence variants affecting diversity of adult human height.

JOURNAL:

Nature genetics May 2008, Vol 40, pp. 609-15

ABSTRACT:

Adult human height is one of the classical complex human traits. We searched for sequence variants that affect height by scanning the genomes of 25,174 Icelanders, 2,876 Dutch, 1,770 European Americans and 1,148 African Americans. We then combined these results with previously published results from the Diabetes Genetics Initiative on 3,024 Scandinavians and tested a selected subset of SNPs in 5,517 Danes. We identified 27 regions of the genome with one or more sequence variants showing significant association with height. The estimated effects per allele of these variants ranged between 0.3 and 0.6 cm and, taken together, they explain around 3.7% of the population variation in height. The genes neighboring the identified loci cluster in biological processes related to skeletal development and mitosis. Association to three previously reported loci are replicated in our analyses, and the strongest association was with SNPs in the ZBTB38 gene. PUBMED: 18391951
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