DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Vitiligo. The EFO term Vitiligo was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Vitiligo

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

C Quan, YQ Ren, LH Xiang, LD Sun, AE Xu, XH Gao, HD Chen, XM Pu, RN Wu, CZ Liang, JB Li, TW Gao, JZ Zhang, XL Wang, J Wang, RY Yang, L Liang, JB Yu, XB Zuo, SQ Zhang, SM Zhang, G Chen, XD Zheng, P Li, J Zhu, YW Li, XD Wei, WS Hong, Y Ye, Y Zhang, WS Wu, H Cheng, PL Dong, DY Hu, Y Li, M Li, X Zhang, HY Tang, XF Tang, SX Xu, SM He, YM Lv, M Shen, HQ Jiang, Y Wang, K Li, XJ Kang, YQ Liu, L Sun, ZF Liu, SQ Xie, CY Zhu, Q Xu, JP Gao, WL Hu, C Ni, TM Pan, Y Li, S Yao, CF He, YS Liu, ZY Yu, XY Yin, FY Zhang, S Yang, Y Zhou, XJ Zhang

TITLE:

Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.

JOURNAL:

Nature genetics Jul 2010, Vol 42, pp. 614-8

ABSTRACT:

We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples from individuals of the Chinese Han (5,910 cases and 9,916 controls) and Chinese Uygur (713 cases and 824 controls) populations. We identified two independent association signals within the major histocompatibility complex (MHC) region (rs11966200, Pcombined=1.48x10(-48), OR=1.90; rs9468925, Pcombined=2.21x10(-33), OR=0.74). Further analyses suggested that the strong association at rs11966200 might reflect the reported association of the HLA-A*3001, HLA-B*1302, HLA-C*0602 and HLA-DRB1*0701 alleles and that the association at rs9468925 might represent a previously unknown HLA susceptibility allele. We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo. PUBMED: 20526339
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