DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Colorectal cancer. The EFO term colorectal cancer was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: colorectal cancer

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

MG Dunlop, SE Dobbins, SM Farrington, AM Jones, C Palles, N Whiffin, A Tenesa, S Spain, P Broderick, LY Ooi, E Domingo, C Smillie, M Henrion, M Frampton, L Martin, G Grimes, M Gorman, C Semple, YP Ma, E Barclay, J Prendergast, JB Cazier, B Olver, S Penegar, S Lubbe, I Chander, LG Carvajal-Carmona, S Ballereau, A Lloyd, J Vijayakrishnan, L Zgaga, I Rudan, E Theodoratou, JM Starr, I Deary, I Kirac, D Kovacević, LA Aaltonen, L Renkonen-Sinisalo, JP Mecklin, K Matsuda, Y Nakamura, Y Okada, S Gallinger, DJ Duggan, D Conti, P Newcomb, J Hopper, MA Jenkins, F Schumacher, G Casey, D Easton, M Shah, P Pharoah, A Lindblom, T Liu, CG Smith, H West, JP Cheadle, R Midgley, DJ Kerr, H Campbell, IP Tomlinson, RS Houlston

TITLE:

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

JOURNAL:

Nature genetics May 2012, Vol 44, pp. 770-6

ABSTRACT:

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. PUBMED: 22634755
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