DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: type II diabetes mellitus

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

T Yamauchi, K Hara, S Maeda, K Yasuda, A Takahashi, M Horikoshi, M Nakamura, H Fujita, N Grarup, S Cauchi, DP Ng, RC Ma, T Tsunoda, M Kubo, H Watada, H Maegawa, M Okada-Iwabu, M Iwabu, N Shojima, HD Shin, G Andersen, DR Witte, T Jørgensen, T Lauritzen, A Sandbæk, T Hansen, T Ohshige, S Omori, I Saito, K Kaku, H Hirose, WY So, D Beury, JC Chan, KS Park, ES Tai, C Ito, Y Tanaka, A Kashiwagi, R Kawamori, M Kasuga, P Froguel, O Pedersen, N Kamatani, Y Nakamura, T Kadowaki

TITLE:

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

JOURNAL:

Nature genetics Oct 2010, Vol 42, pp. 864-8

ABSTRACT:

We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10⁻⁹; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10⁻⁹). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D. PUBMED: 20818381
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