DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Essential tremor. The EFO term essential tremor was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: essential tremor

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

H Stefansson, S Steinberg, H Petursson, O Gustafsson, IH Gudjonsdottir, GA Jonsdottir, ST Palsson, T Jonsson, J Saemundsdottir, G Bjornsdottir, Y Böttcher, T Thorlacius, D Haubenberger, A Zimprich, E Auff, C Hotzy, CM Testa, LA Miyatake, AR Rosen, K Kristleifsson, D Rye, F Asmus, L Schöls, M Dichgans, F Jakobsson, J Benedikz, U Thorsteinsdottir, J Gulcher, A Kong, K Stefansson

TITLE:

Variant in the sequence of the LINGO1 gene confers risk of essential tremor.

JOURNAL:

Nature genetics Mar 2009, Vol 41, pp. 277-9

ABSTRACT:

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected] PUBMED: 19182806
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