GeneSet Information

Tier I GS267845 • GWAS Catalog Data for body mass index in Up to 13,627 European ancestry individuals

DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Body mass index. The EFO term body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: body mass index

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

M Graff, JS Ngwa, T Workalemahu, G Homuth, S Schipf, A Teumer, H Völzke, H Wallaschofski, GR Abecasis, L Edward, C Francesco, S Sanna, P Scheet, D Schlessinger, C Sidore, X Xiao, Z Wang, SJ Chanock, KB Jacobs, RB Hayes, F Hu, RM Van Dam, RJ Crout, ML Marazita, JR Shaffer, LD Atwood, CS Fox, NL Heard-Costa, C White, AC Choh, SA Czerwinski, EW Demerath, TD Dyer, B Towne, N Amin, BA Oostra, CM Van Duijn, MC Zillikens, T Esko, M Nelis, T Nikopensius, A Metspalu, DP Strachan, K Monda, L Qi, KE North, LA Cupples, P Gordon-Larsen, SI Berndt

TITLE:

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.

JOURNAL:

Human molecular genetics Sep 2013, Vol 22, pp. 3597-607

ABSTRACT:

Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P < 5.0 × 10⁻⁸) near FTO (P = 3.72 × 10⁻²³), TMEM18 (P = 3.24 × 10⁻¹⁷), MC4R (P = 4.41 × 10⁻¹⁷), TNNI3K (P = 4.32 × 10⁻¹¹), SEC16B (P = 6.24 × 10⁻⁹), GNPDA2 (P = 1.11 × 10⁻⁸) and POMC (P = 4.94 × 10⁻⁸) as well as a potential secondary signal at the POMC locus (rs2118404, P = 2.4 × 10⁻⁵ after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 18-90) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P < 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages. PUBMED: 23669352
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body mass index (EFO:0004340)

Gene List • 22 Genes

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