DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: Crohn's disease

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

A Franke, DP McGovern, JC Barrett, K Wang, GL Radford-Smith, T Ahmad, CW Lees, T Balschun, J Lee, R Roberts, CA Anderson, JC Bis, S Bumpstead, D Ellinghaus, EM Festen, M Georges, T Green, T Haritunians, L Jostins, A Latiano, CG Mathew, GW Montgomery, NJ Prescott, S Raychaudhuri, JI Rotter, P Schumm, Y Sharma, LA Simms, KD Taylor, D Whiteman, C Wijmenga, RN Baldassano, M Barclay, TM Bayless, S Brand, C Büning, A Cohen, JF Colombel, M Cottone, L Stronati, T Denson, M De Vos, R D'Inca, M Dubinsky, C Edwards, T Florin, D Franchimont, R Gearry, J Glas, A Van Gossum, SL Guthery, J Halfvarson, HW Verspaget, JP Hugot, A Karban, D Laukens, I Lawrance, M Lemann, A Levine, C Libioulle, E Louis, C Mowat, W Newman, J Panés, A Phillips, DD Proctor, M Regueiro, R Russell, P Rutgeerts, J Sanderson, M Sans, F Seibold, AH Steinhart, PC Stokkers, L Torkvist, G Kullak-Ublick, D Wilson, T Walters, SR Targan, SR Brant, JD Rioux, M D'Amato, RK Weersma, S Kugathasan, AM Griffiths, JC Mansfield, S Vermeire, RH Duerr, MS Silverberg, J Satsangi, S Schreiber, JH Cho, V Annese, H Hakonarson, MJ Daly, M Parkes

TITLE:

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

JOURNAL:

Nature genetics Dec 2010, Vol 42, pp. 1118-25

ABSTRACT:

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease. PUBMED: 21102463
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