DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Rheumatoid arthritis. The EFO term rheumatoid arthritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: rheumatoid arthritis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

EA Stahl, S Raychaudhuri, EF Remmers, G Xie, S Eyre, BP Thomson, Y Li, FA Kurreeman, A Zhernakova, A Hinks, C Guiducci, R Chen, L Alfredsson, CI Amos, KG Ardlie, A Barton, J Bowes, E Brouwer, NP Burtt, JJ Catanese, J Coblyn, MJ Coenen, KH Costenbader, LA Criswell, JB Crusius, J Cui, PI de Bakker, PL De Jager, B Ding, P Emery, E Flynn, P Harrison, LJ Hocking, TW Huizinga, DL Kastner, X Ke, AT Lee, X Liu, P Martin, AW Morgan, L Padyukov, MD Posthumus, TR Radstake, DM Reid, M Seielstad, MF Seldin, NA Shadick, S Steer, PP Tak, W Thomson, AH van der Helm-van Mil, IE van der Horst-Bruinsma, CE van der Schoot, PL van Riel, ME Weinblatt, AG Wilson, GJ Wolbink, BP Wordsworth, C Wijmenga, EW Karlson, RE Toes, N de Vries, AB Begovich, J Worthington, KA Siminovitch, PK Gregersen, L Klareskog, RM Plenge

TITLE:

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

JOURNAL:

Nature genetics Jun 2010, Vol 42, pp. 508-14

ABSTRACT:

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles. PUBMED: 20453842
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