DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple sclerosis. The EFO term multiple sclerosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: multiple sclerosis

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

S Nischwitz, S Cepok, A Kroner, C Wolf, M Knop, F Müller-Sarnowski, H Pfister, D Roeske, P Rieckmann, B Hemmer, M Ising, M Uhr, T Bettecken, F Holsboer, B Müller-Myhsok, F Weber

TITLE:

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.

JOURNAL:

Journal of neuroimmunology Oct 2010, Vol 227, pp. 162-6

ABSTRACT:

In a genome wide association study consisting of 592 German multiple sclerosis (MS) patients and 825 controls we were able to replicate the association of the HLA region with MS independently of previous case control studies. No SNPs outside the HLA region reached a genome wide level of significance. Nevertheless, we found suggestive evidence for an association of MS with variants in two new genes, the VAV2 gene and the gene for ZNF433. PUBMED: 20598377
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