DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atrial fibrillation. The EFO term atrial fibrillation was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: atrial fibrillation

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DF Gudbjartsson, H Holm, S Gretarsdottir, G Thorleifsson, GB Walters, G Thorgeirsson, J Gulcher, EB Mathiesen, I Njølstad, A Nyrnes, T Wilsgaard, EM Hald, K Hveem, C Stoltenberg, G Kucera, T Stubblefield, S Carter, D Roden, MC Ng, L Baum, WY So, KS Wong, JC Chan, C Gieger, HE Wichmann, A Gschwendtner, M Dichgans, G Kuhlenbäumer, K Berger, EB Ringelstein, S Bevan, HS Markus, K Kostulas, J Hillert, S Sveinbjörnsdóttir, EM Valdimarsson, ML Løchen, RC Ma, D Darbar, A Kong, DO Arnar, U Thorsteinsdottir, K Stefansson

TITLE:

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

JOURNAL:

Nature genetics Aug 2009, Vol 41, pp. 876-8

ABSTRACT:

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples. PUBMED: 19597491
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