DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atrial fibrillation. The EFO term atrial fibrillation was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: atrial fibrillation

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

EJ Benjamin, KM Rice, DE Arking, A Pfeufer, C van Noord, AV Smith, RB Schnabel, JC Bis, E Boerwinkle, MF Sinner, A Dehghan, SA Lubitz, RB D'Agostino, T Lumley, GB Ehret, J Heeringa, T Aspelund, C Newton-Cheh, MG Larson, KD Marciante, EZ Soliman, F Rivadeneira, TJ Wang, G Eiríksdottir, D Levy, BM Psaty, M Li, AM Chamberlain, A Hofman, RS Vasan, TB Harris, JI Rotter, WH Kao, SK Agarwal, BH Stricker, K Wang, LJ Launer, NL Smith, A Chakravarti, AG Uitterlinden, PA Wolf, N Sotoodehnia, A Köttgen, CM van Duijn, T Meitinger, M Mueller, S Perz, G Steinbeck, HE Wichmann, KL Lunetta, SR Heckbert, V Gudnason, A Alonso, S Kääb, PT Ellinor, JC Witteman

TITLE:

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.

JOURNAL:

Nature genetics Aug 2009, Vol 41, pp. 879-81

ABSTRACT:

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)). PUBMED: 19597492
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