DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Cancer (pleiotropy). The EFO term lung carcinoma, estrogen-receptor negative breast cancer, colorectal cancer, ovarian endometrioid carcinoma, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: lung carcinoma, estrogen-receptor negative breast cancer, colorectal cancer, ovarian endometrioid carcinoma, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

G Fehringer, P Kraft, PD Pharoah, RA Eeles, N Chatterjee, FR Schumacher, JM Schildkraut, S Lindström, P Brennan, H Bickeböller, RS Houlston, MT Landi, N Caporaso, A Risch, A Amin Al Olama, SI Berndt, EL Giovannucci, H Grönberg, Z Kote-Jarai, J Ma, K Muir, MJ Stampfer, VL Stevens, F Wiklund, WC Willett, EL Goode, JB Permuth, HA Risch, BM Reid, S Bezieau, H Brenner, AT Chan, J Chang-Claude, TJ Hudson, JK Kocarnik, PA Newcomb, RE Schoen, ML Slattery, E White, MA Adank, H Ahsan, K Aittomäki, L Baglietto, C Blomquist, F Canzian, K Czene, I Dos-Santos-Silva, AH Eliassen, JD Figueroa, D Flesch-Janys, O Fletcher, M Garcia-Closas, MM Gaudet, N Johnson, P Hall, A Hazra, R Hein, A Hofman, JL Hopper, A Irwanto, M Johansson, R Kaaks, MG Kibriya, P Lichtner, J Liu, E Lund, E Makalic, A Meindl, B Müller-Myhsok, TA Muranen, H Nevanlinna, PH Peeters, J Peto, RL Prentice, N Rahman, MJ Sanchez, DF Schmidt, RK Schmutzler, MC Southey, R Tamimi, RC Travis, C Turnbull, AG Uitterlinden, Z Wang, AS Whittemore, XR Yang, W Zheng, DD Buchanan, G Casey, DV Conti, CK Edlund, S Gallinger, RW Haile, M Jenkins, L Le Marchand, L Li, NM Lindor, SL Schmit, SN Thibodeau, MO Woods, T Rafnar, J Gudmundsson, SN Stacey, K Stefansson, P Sulem, YA Chen, JP Tyrer, DC Christiani, Y Wei, H Shen, Z Hu, XO Shu, K Shiraishi, A Takahashi, Y Bossé, M Obeidat, D Nickle, W Timens, ML Freedman, Q Li, D Seminara, SJ Chanock, J Gong, U Peters, SB Gruber, CI Amos, TA Sellers, DF Easton, DJ Hunter, CA Haiman, BE Henderson, RJ Hung

TITLE:

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

JOURNAL:

Cancer research Sep 2016, Vol 76, pp. 5103-14

ABSTRACT:

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR. PUBMED: 27197191
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