DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Forced vital capacity. The EFO term vital capacity was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: vital capacity

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

DW Loth, M Soler Artigas, SA Gharib, LV Wain, N Franceschini, B Koch, TD Pottinger, AV Smith, Q Duan, C Oldmeadow, MK Lee, DP Strachan, AL James, JE Huffman, V Vitart, A Ramasamy, NJ Wareham, J Kaprio, XQ Wang, H Trochet, M Kähönen, C Flexeder, E Albrecht, LM Lopez, K de Jong, B Thyagarajan, AC Alves, S Enroth, E Omenaas, PK Joshi, T Fall, A Viñuela, LJ Launer, LR Loehr, M Fornage, G Li, JB Wilk, W Tang, A Manichaikul, L Lahousse, TB Harris, KE North, AR Rudnicka, J Hui, X Gu, T Lumley, AF Wright, ND Hastie, S Campbell, R Kumar, I Pin, RA Scott, KH Pietiläinen, I Surakka, Y Liu, EG Holliday, H Schulz, J Heinrich, G Davies, JM Vonk, M Wojczynski, A Pouta, A Johansson, SH Wild, E Ingelsson, F Rivadeneira, H Völzke, PG Hysi, G Eiriksdottir, AC Morrison, JI Rotter, W Gao, DS Postma, WB White, SS Rich, A Hofman, T Aspelund, D Couper, LJ Smith, BM Psaty, K Lohman, EG Burchard, AG Uitterlinden, M Garcia, BR Joubert, WL McArdle, AB Musk, N Hansel, SR Heckbert, L Zgaga, JB van Meurs, P Navarro, I Rudan, YM Oh, S Redline, DL Jarvis, JH Zhao, T Rantanen, GT O'Connor, S Ripatti, RJ Scott, S Karrasch, H Grallert, NC Gaddis, JM Starr, C Wijmenga, RL Minster, DJ Lederer, J Pekkanen, U Gyllensten, H Campbell, AP Morris, S Gläser, CJ Hammond, KM Burkart, J Beilby, SB Kritchevsky, V Gudnason, DB Hancock, OD Williams, O Polasek, T Zemunik, I Kolcic, MF Petrini, M Wjst, WJ Kim, DJ Porteous, G Scotland, BH Smith, A Viljanen, M Heliövaara, JR Attia, I Sayers, R Hampel, C Gieger, IJ Deary, HM Boezen, A Newman, MR Jarvelin, JF Wilson, L Lind, BH Stricker, A Teumer, TD Spector, E Melén, MJ Peters, LA Lange, RG Barr, KR Bracke, FM Verhamme, J Sung, PS Hiemstra, PA Cassano, A Sood, C Hayward, J Dupuis, IP Hall, GG Brusselle, MD Tobin, SJ London

TITLE:

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

JOURNAL:

Nature genetics Jul 2014, Vol 46, pp. 669-77

ABSTRACT:

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease. PUBMED: 24929828
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