DESCRIPTION:
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans. Generated by gene2mesh v. 1.1.1
LABEL:
Presenilin-1
SCORE TYPE:
Binary
DATE ADDED:
DATE UPDATED:
SPECIES:
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GeneWeaver