DESCRIPTION:

QTL Associated with Neural tumor susceptibility. On Chromosome 10 with a LOD score= , p-value =0.0041. From a(n) of

LABEL:

QTL-Schws1-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Koelsch BU, Fischer C, Neibecker M, Schmitt N, Schmidt O, Rajewsky MF, Kindler-Röhrborn A

TITLE:

Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system.

JOURNAL:

International journal of cancer. Journal international du cancer None None, Vol 118, pp. 108-14

ABSTRACT:

1. Int J Cancer. 2006 Jan 1;118(1):108-14. Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system. Koelsch BU(1), Fischer C, Neibecker M, Schmitt N, Schmidt O, Rajewsky MF, Kindler-Röhrborn A. Author information: (1)Department of Neuropathology, University of Bonn, Medical Center, Bonn, Germany. The inbred BD rat strains constitute a model system for analysis of the genetic basis of susceptibility or resistance to the development of neural tumors, as they exhibit distinct strain-specific differences regarding the sensitivity to tumor induction by the alkylating carcinogen N-ethyl-N-nitrosourea (EtNU). Among the different BD strains, BDIX and BDIV rats, respectively, are either highly susceptible or entirely resistant to the development of EtNU-induced malignant schwannomas of the peripheral nervous system (PNS), predominantly of the trigeminal nerves. We have previously mapped one locus associated with susceptibility/resistance to schwannoma induction to the telomeric third of chromosome 10 (Mss1) in segregating (BDIX x BDIV) crosses. We report on the genetic mapping of 6 further loci controlling tumor incidence or survival time on chromosomes 1 (Mss2), 3 (Mss3), 6 (Mss4), 13 (Mss5) and 15 (Mss6) as well as on chromosome 10 (Mss7) close to the centromere. Interestingly, most of these loci mediate gender-specific effects of variable strength ranging from minor influences on tumor development to complete tumor resistance. The gender specificity is reflected by the fact that male (BDIX x BDIV) F2 rats exhibit a 2-fold higher incidence of EtNU-induced schwannomas than females as well as a shorter survival time. A number of human nervous system tumors too arise with a marked gender bias. Genes mediating gender-specific predisposition of developing malignant schwannomas in the rat may be relevant for the human individual risk of developing nervous system tumors. Copyright 2005 Wiley-Liss, Inc. PMID: 16003739 [PubMed - indexed for MEDLINE] PUBMED: 16003739
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