1. Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated
from and associated with blood pressure in Dahl congenic rats.
Duong C(1), Charron S, Xiao C, Hamet P, Ménard A, Roy J, Deng AY.
Author information:
(1)Research Centre, Centre Hospitalier de l'Université de Montréal (CHUM),
Montréal, Québec, Canada.
Blood pressure (BP) is largely determined by quantitative trait loci (QTLs) in
Dahl salt-sensitive (DSS) rats. Little is known about QTLs controlling kidney
(K), cardiac (C), and aortic (A) mass (i.e. Km, Cm, and Am, respectively) of DSS
rats independent of BP. Their identification can facilitate our understanding of
end organ damage. In this work, 36 congenic strains were employed to define QTLs
for Km, Cm, and Am either independent of or associated with BP. Five new QTLs,
i.e., KmQTLs, that influence Km independent of Cm, Am, and BP were defined. Four
new CakmQTLs were defined for Cm, Am, and Km independent of BP. Among them, the
CakmC10QTL1 interval contained 13 genes and undefined loci, and none was known to
influence the phenotypes in question, paving the way for a novel gene discovery.
Among 17 individual QTLs for BP, 14 also affected Cm, Km, and Am, i.e., they are
BpcakmQTLs. In contrast, one BpQTL had no effect on Cm, Am, and Kam. Therefore,
BP and Cm, Am, and Km have distinct and shared genetic determinants. The
discovery of individual Km and Cakm QTLs will likely facilitate the
identification of mechanisms underlying renal, cardiac, and/or aortic hypertrophy
independent of hypertension.
PMID: 17143582 [PubMed - indexed for MEDLINE]
PUBMED: 17143582
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