DESCRIPTION:

QTL Associated with Carrageenan-induced inflammation. On Chromosome 2 with a LOD score= 2.7, p-value =0.009. From a(n) F2;intercross of F344xLEW

LABEL:

QTL-Cari2-Rat-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Laes JF, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C

TITLE:

Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.

JOURNAL:

Cytogenetics and cell genetics None None, Vol 92, pp. 130-3

ABSTRACT:

1. Cytogenet Cell Genet. 2001;92(1-2):130-3. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF(1), Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C. Author information: (1)Université Libre de Bruxelles, IBMM, Gosselies, Belgium. We established a radiation hybrid (RH) map of several genes and anonymous markers in the lower half of rat chromosome 2, a chromosome region that contains quantitative trait loci (QTLs) for blood pressure, diabetes and inflammatory response. Two of the newly localized genes (Crh and Il6r) encode proteins involved in the regulation of inflammatory and immune events. Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates. PMID: 11306811 [PubMed - indexed for MEDLINE] PUBMED: 11306811
Find other GeneSets from this publication