DESCRIPTION:

QTL Associated with Joint/bone inflammation. On Chromosome 5 with a LOD score= 5, p-value =0.001. From a(n) intercross of QTL Associated with Blood pressure. On Chromosome 10 with a LOD score= , p-value =0.005. From a(n) backcross of WKYxSHRSP

LABEL:

QTL-Bp133-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Kreutz R, Hübner N, James MR, Bihoreau MT, Gauguier D, Lathrop GM, Ganten D, Lindpaintner K

TITLE:

Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

JOURNAL:

Proceedings of the National Academy of Sciences of the United States of America None None, Vol 92, pp. 8778-82

ABSTRACT:

1. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8778-82. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Kreutz R(1), Hübner N, James MR, Bihoreau MT, Gauguier D, Lathrop GM, Ganten D, Lindpaintner K. Author information: (1)Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. We have previously identified a locus on rat chromosome 10 as carrying a major hypertension gene, BP/SP-1. The 100:1 odds support interval for this gene extended over a 35-centimorgan (cM) region of the chromosome that included the angiotensin I-converting enzyme (ACE) locus as demonstrated in a cross between the stroke-prone spontaneously hypertensive rat (SHRSPHD) and the normotensive Wistar-Kyoto (WKY-0HD) rat. Here we report on the further characterization of BP/SP-1, using a congenic strain, WKY-1HD. WKY-1HD animals carry a 6-cM chromosomal fragment genotypically identical with SHRSPHD on chromosome 10, 26 cM away from the ACE locus. Higher blood pressures in the WKY-1HD strain compared with the WKY-0HD strain, as well as absence of linkage of the chromosome 10 region to blood pressure in an F2 (WKY-1HD x SHRSPHD) population suggested the existence of a quantitative trait locus, termed BP/SP-1a, that lies within the SHRSP-congenic region in WKY-1HD. Linkage analysis in the F2 (WKY-0HD x SHRSPHD) cross revealed that BP/SP-1a is linked to basal blood pressure, whereas a second locus on chromosome 10, termed BP/SP-1b, that maps closer to the ACE locus cosegregates predominantly with blood pressure after exposure to excess dietary NaCl. Thus, we hypothesize that the previously reported effect of BP/SP-1 represents a composite phenotype that can be dissected into at least two specific components on the basis of linkage data and congenic experimentation. One of the loci identified, BP/SP-1a, represents the most precisely mapped locus affecting blood pressure that has so far been characterized by random-marker genome screening. PMCID: PMC41050 PMID: 7568016 [PubMed - indexed for MEDLINE] PUBMED: 7568016
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