DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 5 with a LOD score= , p-value =0.001. From a(n) of

LABEL:

QTL-Bp139-Rat-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Pravenec M, Kren V, Krenová D, Zídek V, Simáková M, Musilová A, Vorlícek J, Lezin ES, Kurtz TW

TITLE:

Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat.

JOURNAL:

Physiological research / Academia Scientiarum Bohemoslovaca None None, Vol 52, pp. 285-9

ABSTRACT:

1. Physiol Res. 2003;52(3):285-9. Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat. Pravenec M(1), Kren V, Krenová D, Zídek V, Simáková M, Musilová A, Vorlícek J, Lezin ES, Kurtz TW. Author information: (1)Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. pravenec@biomed.cas.cz Total genome scans of genetically segregating populations derived from spontaneously hypertensive rats (SHR) and other rat models of essential hypertension suggested a presence of quantitative trait loci (QTL) regulating blood pressure on multiple chromosomes, including chromosome 5. The objective of the current study was to test directly a hypothesis that chromosome 5 of the SHR carries a blood pressure regulatory QTL. A new congenic strain was derived by replacing a segment of chromosome 5 in the SHR/Ola between the D5Wox20 and D5Rat63 markers with the corresponding chromosome segment from the normotensive Brown Norway (BN/Crl) rat. Arterial pressures were directly monitored in conscious, unrestrained rats by radiotelemetry. The transfer of a segment of chromosome 5 from the BN strain onto the SHR genetic background was associated with a significant decrease of systolic blood pressure, that was accompanied by amelioration of renal hypertrophy. The heart rates were not significantly different in the SHR compared to SHR chromosome 5 congenic strain. The findings of the current study demonstrate that gene(s) with major effects on blood pressure and renal mass exist in the differential segment of chromosome 5 trapped within the new SHR.BN congenic strain. PMID: 12790759 [PubMed - indexed for MEDLINE] PUBMED: 12790759
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