1. Obesity (Silver Spring). 2009 Jun;17(6):1215-9. doi: 10.1038/oby.2008.658. Epub
2009 Feb 19.
Genes on rat chromosomes 3, 5, 10, and 16 are linked with facets of metabolic
syndrome.
Baguhl R(1), Wilke B, Klöting N, Klöting I.
Author information:
(1)Department of Laboratory Animal Science, Medical Faculty, University
Greifswald, Karlsburg, Germany.
WOKW (Wistar Ottawa Karlsburg W) rats develop metabolic syndrome closely
resembling human disorder. In crossing studies between disease-prone WOKW and
disease-resistant DA (Dark Agouti) rats, several quantitative trait loci (QTLs)
were mapped. To prove the in vivo relevance of QTLs, congenic DA.WOKW rats,
briefly termed DA.3aW, DA.3bW, DA.5W, DA.10W, and DA.16W, were generated by
transferring chromosomal regions of WOKW chromosomes 3, 5, 10, and 16 onto DA
genetic background. Male (n=12) and female (n=12) rats of each congenic strain
and their parental strain DA were characterized for adiposity index (AI), serum
leptin, and serum insulin as well as serum cholesterol and serum triglycerides as
single facets of metabolic syndrome at the age of 30 weeks. The data showed a
significant higher AI for male and female DA.3aW and female DA.16W compared with
DA. Serum leptin was significantly elevated in male and female DA.3aW, DA.10W,
and DA.16W rats in comparison with DA. Rats of both sexes of DA.10W and female
DA.16W showed significantly elevated serum insulin in comparison to DA. Female
rats of all congenics had significantly higher serum cholesterol compared with
DA, while males did not differ. Finally, triglycerides were only elevated in male
DA.16W. The results demonstrate an involvement of WOKW chromosomes 3, 5, 10, and
16 in developing facets of the metabolic syndrome.
PMID: 19584880 [PubMed - indexed for MEDLINE]
PUBMED: 19584880
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