1. Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.
Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown
Norway rat, to RNO5.
Gould KA(1), Pandey J, Lachel CM, Murrin CR, Flood LA, Pennington KL, Schaffer
BS, Tochacek M, McComb RD, Meza JL, Wendell DL, Shull JD.
Author information:
(1)Department of Genetics, Cell Biology and Anatomy, University of Nebraska
Medical Center, Omaha, Nebraska 68198, USA. kagould@unmc.edu
In certain rat strains, chronic estrogen administration can lead to pyometritis,
an inflammation of the uterus accompanied by infection and the accumulation of
intraluminal pus. In this article, we report that the Brown Norway (BN) rat is
highly susceptible to pyometritis induced by 17beta-estradiol (E2). The
susceptibility of the BN rat to E2-induced pyometritis appears to segregate as a
recessive trait in crosses to the resistant August x Copenhagen Irish (ACI)
strain. In a (BN x ACI)F(2) population, we find strong evidence for a major
genetic determinant of susceptibility to E2-induced pyometritis on rat chromosome
5 (RNO5). Our data are most consistent with a model in which the BN allele of
this locus, designated Eutr1 (Estrogen-induced uterine response 1), acts in an
incompletely dominant manner to control E2-induced pyometritis. Furthermore, we
have confirmed the contribution of Eutr1 to E2-induced uterine pyometritis using
an RNO5 congenic rat strain. In addition to Eutr1, we obtained evidence
suggestive of linkage for five additional loci on RNO2, 4, 11, 17, and X that
control susceptibility to E2-induced pyometritis in the (BN x ACI)F(2)
population.
PMID: 16284801 [PubMed - indexed for MEDLINE]
PUBMED: 16284801
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