DESCRIPTION:

QTL Associated with Insulin level. On Chromosome X with a LOD score= 0, p-value =. From a(n) intercross of BN/CrjxWBN/KobSlc

LABEL:

QTL-Insul4-Rat-Chr X

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Tsuji A, Nishikawa T, Mori M, Suda K, Nishimori I, Nishimura M

TITLE:

Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat.

JOURNAL:

Genomics None None, Vol 74, pp. 365-9

ABSTRACT:

1. Genomics. 2001 Jun 15;74(3):365-9. Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. Tsuji A(1), Nishikawa T, Mori M, Suda K, Nishimori I, Nishimura M. Author information: (1)Institute for Experimental Animals, Hamamatsu University School of Medicine, Handa-cho 3600, Hamamatsu, 431-3192, Japan. A causative gene mutation is still undefined in approximately half of patients with hereditary pancreatitis, and no genetic factor has been identified in most patients with sporadic chronic pancreatitis. To identify a pancreatitis-associated gene, we performed a quantitative trait locus (QTL) analysis for the traits of chronic pancreatitis and diabetes mellitus in WBN/Kob rats. We identified two highly significant QTLs for chronic pancreatitis and/or hyperinsulinemia on chromosomes 7 and X. These QTLs were located on completely different chromosomal regions from those of causative genes that have been reported for human chronic pancreatitis: PRSS1, CFTR, and SPINK1. For these QTLs, prevalences of the WBN/Kob allele significantly increased in the rats with chronic pancreatitis. These findings indicate that chronic pancreatitis in WBN/Kob rats is controlled by multiple genes, and a genetic analysis in WBN/Kob rats might be useful for gene targeting for human chronic pancreatitis. Copyright 2001 Academic Press. PMID: 11414764 [PubMed - indexed for MEDLINE] PUBMED: 11414764
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