DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 1 with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Bp107-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Monti J, Plehm R, Schulz H, Ganten D, Kreutz R, Hübner N

TITLE:

Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10.

JOURNAL:

Human molecular genetics None None, Vol 12, pp. 435-9

ABSTRACT:

1. Hum Mol Genet. 2003 Feb 15;12(4):435-9. Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Monti J(1), Plehm R, Schulz H, Ganten D, Kreutz R, Hübner N. Author information: (1)Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buch, Germany. We have used inbred and congenic rat strains in F(2) segregation studies to discover epistasis in a polygenic model of hypertension. Previously, we have found evidence that the presence of a blood pressure quantitative trait locus (QTL) on chromosome 1 is conditional upon the allele status of chromosome 10. To prove the existence of an epistatic interaction we have analyzed congenic strains for chromosome 1 and 10 carrying high blood pressure QTL alleles from the spontaneously hypertensive rat on a normotensive background of the Wistar-Kyoto (WKY) rat. Additionally, a double congenic strain was developed with both chromosome 1 and 10 high blood pressure QTL alleles on the WKY background. Analysis of variance for blood pressure phenotypes as determined by radiotelemetry showed a significant effect for chromosome 10 but not chromosome 1 QTL alleles and demonstrated a significant interaction between the two loci (P<0.05). The interaction accounted for 5 mmHg of blood pressure. Thus, the identification of epistasis is critical to the understanding of the quantitative nature of blood pressure genetics. PMID: 12566390 [PubMed - indexed for MEDLINE] PUBMED: 12566390
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