DESCRIPTION:

QTL Associated with Glucose level. On Chromosome X with a LOD score= , p-value =0.001. From a(n) backcross of SDTxBN

LABEL:

QTL-Gluco15-Rat-Chr X

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Masuyama T, Fuse M, Yokoi N, Shinohara M, Tsujii H, Kanazawa M, Kanazawa Y, Komeda K, Taniguchi K

TITLE:

Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 304, pp. 196-206

ABSTRACT:

1. Biochem Biophys Res Commun. 2003 Apr 25;304(1):196-206. Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat. Masuyama T(1), Fuse M, Yokoi N, Shinohara M, Tsujii H, Kanazawa M, Kanazawa Y, Komeda K, Taniguchi K. Author information: (1)Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, 020-8550, Iwate, Japan. t.masuyama@tba.t-com.ne.jp <t.masuyama@tba.t-com.ne.jp> The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male (BNxSDT)xSDT backcrosses. Male SDT rats exhibited glucose intolerance at 20 weeks, and spontaneously developed diabetes with the incidence of 100% at 38 weeks, and glucose intolerance is well associated with the development of diabetes. The QTL analysis identified three highly significant QTLs (Gisdt1, Gisdt2, and Gisdt3) for glucose intolerance on rat chromosomes 1, 2, and X, respectively. The SDT allele for these QTLs significantly exacerbated glucose intolerance. Furthermore, synergistic interactions among these QTLs were detected. These findings indicate that diabetic features in SDT rats are inherited as polygenic traits and that SDT rats would provide insights into genetics of human type 2 diabetes. PMID: 12705906 [PubMed - indexed for MEDLINE] PUBMED: 12705906
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