DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 14 with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Scl59-Rat-Chr 14

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Asahina M, Haruyama W, Ichida Y, Sakamoto M, Sato M, Imaizumi K

TITLE:

Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.

JOURNAL:

Journal of lipid research None None, Vol 50, pp. 41-6

ABSTRACT:

1. J Lipid Res. 2009 Jan;50(1):41-6. doi: 10.1194/jlr.M800135-JLR200. Epub 2008 Aug 27. Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats. Asahina M(1), Haruyama W, Ichida Y, Sakamoto M, Sato M, Imaizumi K. Author information: (1)Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan. We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation cross of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines and carried out expression and sequencing analyses. Here we narrowed Dihc2 to a region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo. PMID: 18753676 [PubMed - indexed for MEDLINE] PUBMED: 18753676
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