DESCRIPTION:

QTL Associated with Body weight. On Chromosome 1 with a LOD score= 5.1, p-value =. From a(n) F1xSHR of SHRx(BB/OKxSHR)F1

LABEL:

QTL-Bw20-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Kovács P, Voigt B, Klöting I

TITLE:

Congenic strain confirms putative quantitative trait locus for body weight in the rat.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 9, pp. 294-6

ABSTRACT:

1. Mamm Genome. 1998 Apr;9(4):294-6. Congenic strain confirms putative quantitative trait locus for body weight in the rat. Kovács P(1), Voigt B, Klöting I. Author information: (1)Department of Laboratory Animal Sciences, University of Greifswald, Germany. Quantitative trait loci (QTLs) affecting body weight were investigated in the backcross population derived from non-diabetic BB/OK and spontaneously hypertensive rat (SHR) strains. The F1 hybrids were backcrossed onto SHR rats, and QTL analysis was performed separately with the resulting backcross populations for each sex on Chromosomes (Chrs) 1, 3, 4, 10, 13, and 18. The body weight was determined at the age of 14 weeks, and the statistical analysis was performed with MAPMAKER/QTL 1.1b computer program. According to the stringent threshold for a lod score of 3.0, markers on Chr 1 were found to be linked with body weight. The QTL with a peak lod score (5.1) on Chr 1 for a male population was located within markers Igf2 and D1Mgh12. In contrast, in the female population the body weight affecting QTL (lod = 5.7) on Chr 1 was located between the D1Mit3 and Lsn markers. The existence of QTLs on Chr 1 affecting body weight in the male population was confirmed by congenic BB.Sa rats, carrying chromosomal region of SHR (Sa-Igf2) on the genetic background of BB rat. PMID: 9530625 [PubMed - indexed for MEDLINE] PUBMED: 9530625
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