DESCRIPTION:

QTL Associated with Stroke susceptibility. On Chromosome 5 with a LOD score= 4.7, p-value =. From a(n) F2 of SHRSP x SHR

LABEL:

QTL-Strs2-Rat-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Rubattu S, Volpe M, Kreutz R, Ganten U, Ganten D, Lindpaintner K

TITLE:

Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease.

JOURNAL:

Nature genetics None None, Vol 13, pp. 429-34

ABSTRACT:

1. Nat Genet. 1996 Aug;13(4):429-34. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease. Rubattu S(1), Volpe M, Kreutz R, Ganten U, Ganten D, Lindpaintner K. Author information: (1)Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. Comment in Nat Genet. 1996 Aug;13(4):384-5. Stroke is a complex disorder with a poorly understood multifactorial and polygenic aetiology. We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a genome-wide screen in the resultant F2 cohort where latency until stroke, but not hypertension (a major confounder) segregated. We identified three major quantitative trait loci, STR1-3, with lod scores of 7.4, 4.7 and 3.0, respectively, that account for 28% of the overall phenotypic variance. STR2 colocalizes with the genes encoding atrial and brain natriuretic factor, peptides with important vasoactive properties. Our results demonstrate the existence of primary, blood pressure-independent genetic factors predisposing to a complex form of stroke. PMID: 8696337 [PubMed - indexed for MEDLINE] PUBMED: 8696337
Find other GeneSets from this publication