DESCRIPTION:

QTL Associated with Cardiac mass. On Chromosome 3 with a LOD score= 2.1, p-value =. From a(n) of (SxR)xS

LABEL:

QTL-Cm14-Rat-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Cicila GT, Choi C, Dene H, Lee SJ, Rapp JP

TITLE:

Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 10, pp. 112-6

ABSTRACT:

1. Mamm Genome. 1999 Feb;10(2):112-6. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Cicila GT(1), Choi C, Dene H, Lee SJ, Rapp JP. Author information: (1)Department of Physiology and Molecular Medicine, Block Health Science Building, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio, 43614-5804 USA. Interval mapping was used to identify putative quantitative trait loci (QTL) for blood pressure and cardiac mass on Chromosome (Chr) 3 in F1(S x R) x S population of 150 rats raised on an 8% NaCl diet. Two genetic markers 95.7 cM apart, D3Wox3 and D3Mco5 (tightly linked to Edn3), showed "suggestive" linkage to blood pressure (LOD = 2.0 and 1.8 respectively). In addition, D3Wox3 showed "suggestive" linkage to heart weight (LOD = 2.5), and D3Mco5 showed "suggestive" linkage to body weight-adjusted heart weight (LOD = 2.1). Congenic rats (designated S.R-Edn3) were constructed by introgressing the R-rat Edn3 allele (and flanking loci) into the S strain. On a 2% NaCl diet, S.R-Edn3 rats had lower blood pressure (21.4 mm Hg, P = 0. 0005) and heart weight (59 mg, P = 0.0038) compared with S rats, confirming the existence of a blood pressure QTL on Chr 3 near Edn3 even though QTL linkage analysis of blood pressure did not achieve stringent statistical criteria for significance. The results of the congenic experiment and the large distance between the two putative QTL suggest the presence of at least two independent blood pressure/cardiac mass QTL detectable on Chr 3 in the Dahl rat model of genetic hypertension. PMID: 9922389 [PubMed - indexed for MEDLINE] PUBMED: 9922389
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