DESCRIPTION:

QTL Associated with Glucose level. On Chromosome 18 with a LOD score= 2.33, p-value =0.0074. From a(n) F2;backcross of BB/OKxDA

LABEL:

QTL-Iddm4-Rat-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Klöting I, Schmidt S, Kovacs P

TITLE:

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 245, pp. 483-6

ABSTRACT:

1. Biochem Biophys Res Commun. 1998 Apr 17;245(2):483-6. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Klöting I(1), Schmidt S, Kovacs P. Author information: (1)Department of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany. By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for diabetes development in the BB rat. Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Because mapping results need not be consistent among different crosses, we genetically analysed a new cross population using diabetic BB/OK and diabetes-resistant SHR/Mol rats analysing 73 microsatellite markers. The genetic analysis of Iddm1 and Iddm2 homozygous [(BB/OK x SHR)F1 x BB/OK] first backcross hybrids (BC1) confirmed the action of Iddm3 and one predisposing non-MHC locus, Iddm4, near Ighe/D6Mgh2 on chromosome 6 and one protective locus, Iddm5r(esistance), detected around Igf2/Tnt on chromosome 1. From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes. PMID: 9571179 [PubMed - indexed for MEDLINE] PUBMED: 9571179
Find other GeneSets from this publication