DESCRIPTION:

QTL Associated with Glucose level. On Chromosome X with a LOD score= , p-value =. From a(n) of BB-DP/HrixBN/Mol QTL Associated with Glucose level. On Chromosome 1 with a LOD score= , p-value =. From a(n) of QTL Associated with Glucose level. On Chromosome X with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Iddm5-Rat-Chr X

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Klöting I, Vogt L, Serikawa T

TITLE:

Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.

JOURNAL:

Diabete & metabolisme None None, Vol 21, pp. 338-44

ABSTRACT:

1. Diabete Metab. 1995 Dec;21(5):338-44. Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Klöting I(1), Vogt L, Serikawa T. Author information: (1)Department of Laboratory Animal Science, Gerhardt Katsch Institute of Diabetes, University of Greifswald, Karlsburg, Germany. The spontaneously diabetic BB rat is a well-established animal model of human insulin-dependent diabetes mellitus. Besides the lymphopenia gene (Iddm 1) and the MHC class-II genes of the RT1u haplotype (Iddm 2), at least one other non-MHC gene (Iddm 3) is considered essential for diabetes development. To investigate the participation of this third gene in the development of diabetes in our BB/OK rat subline, we analysed 119 [(BB/OK x DA)F1 x BB/OK] first backcross hybrids phenotypically and genotypically. Genotyping with 5 classical and 28 polymorphic microsatellite markers indicated that the third gene is located on chromosome 18, about 22 +/- 7 cM distal from the Olf locus (Iod score = 2.33). Significantly more diabetics than Iddm 1 and Iddm 2 homozygous nondiabetic subjects were homozygous for this locus. Interacting genes located on chromosomes X and/or 1 seem to be involved. PMID: 8586150 [PubMed - indexed for MEDLINE] PUBMED: 8586150
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