DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 10 with a LOD score= 4.8, p-value =1.00E-04. From a(n) F2 of "SS/Jr x MNS, LEW x SS/Jr, WKY x SS/Jr"

LABEL:

QTL-Bp9-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Deng Y, Rapp JP

TITLE:

Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

JOURNAL:

Nature genetics None None, Vol 1, pp. 267-72

ABSTRACT:

1. Nat Genet. 1992 Jul;1(4):267-72. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y(1), Rapp JP. Author information: (1)Department of Medicine, Medical College of Ohio, Toledo 43699. We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains. PMID: 1363813 [PubMed - indexed for MEDLINE] PUBMED: 1363813
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