DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 10 with a LOD score= 19, p-value =1.00E-04. From a(n) F2 of SHRSP x WKY QTL Associated with Blood pressure. On Chromosome 5 with a LOD score= 4.5, p-value =1.00E-04. From a(n) F2 of SS/Jr x LEW

LABEL:

QTL-Bp7-Rat-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Deng AY, Dene H, Pravenec M, Rapp JP

TITLE:

Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

JOURNAL:

The Journal of clinical investigation None None, Vol 93, pp. 2701-9

ABSTRACT:

1. J Clin Invest. 1994 Jun;93(6):2701-9. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY(1), Dene H, Pravenec M, Rapp JP. Author information: (1)Department of Physiology and Biophysics, Medical College of Ohio, Toledo 43699. The endothelin system, consisting of a series of potent vasoconstrictor peptides and their receptors, is potentially important in the control of blood pressure. We found that the gene coding for endothelin-2 (ET2), also known as vasoctive intestine peptide, cosegregated strongly with systolic blood pressure in a F2 population [F2(S x LEW)] derived from a cross of the Dahl salt-sensitive (S) rat and the Lewis (LEW/NCrlBR) (LEW) rat. The ET2 locus was assigned to rat chromosome 5. The testis-specific histone (HITH) locus also strongly cosegregated with blood pressure in the F2(S x LEW) population and was assigned to rat chromosome 17. Genetic maps of the regions containing the quantitative trait loci (QTL) for blood pressure on chromosomes 5 and 17 were constructed and the QTL were localized using the MAPMAKER/QTL program. The rat genes for endothelin-1, endothelin-3, and endothelin receptor A did not cosegregate with blood pressure in several F2 populations tested and were assigned to rat chromosomes 17, 3, and 19, respectively. Endothelin receptor B cosegregated weakly with blood pressure and was provisionally assigned to rat chromosome 15. We conclude that, in the rat, one new blood pressure QTL is located on chromosome 5 marked by the ET2 locus and another new QTL is located on chromosome 17 near the HITH locus. PMCID: PMC294520 PMID: 8201007 [PubMed - indexed for MEDLINE] PUBMED: 8201007
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