DESCRIPTION:

QTL Associated with Urine glucose level. On Chromosome 6 with a LOD score= , p-value =1.00E-04. From a(n) of

LABEL:

QTL-Iddm18-Rat-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Klöting I, van den Brandt J, Kuttler B

TITLE:

Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 283, pp. 399-405

ABSTRACT:

1. Biochem Biophys Res Commun. 2001 May 4;283(2):399-405. Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. Klöting I(1), van den Brandt J, Kuttler B. Author information: (1)Department of Laboratory Animal Science, University Greifswald, Karlsburg, 17495, Germany. kloeting@uni-greifswald.de Diabetes in BB rats share many common features with human type 1 diabetes. One of them is the complex and polygenic nature of disease. Analysis of cross hybrids of diabetic BB/OK rats and rats of different diabetes-resistant strains has demonstrated that beside the MHC genes, Iddm1 and the lymphopenia, Iddm2, additional non-MHC genes are involved in diabetes development. To study the importance of the non-MHC genes, Iddm4 and Iddm3, two congenic BB.SHR rat strains were generated by recombining a segment of the SHR chromosome 6 (Iddm4; termed BB.6S; 15cM) or chromosome 18 (Iddm3; termed BB.18S; 24cM) into the BB/OK background by serial backcrossing and marker-aided selection. The characterization of both congenic strains demonstrates a drastic reduction of diabetes frequency in comparison to the BB/OK strain (86% vs 14% and 34%). It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2. PMID: 11327715 [PubMed - indexed for MEDLINE] PUBMED: 11327715
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