DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 5 with a LOD score= 6, p-value =. From a(n) of

LABEL:

QTL-Scl44-Rat-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Asahina M, Sato M, Imaizumi K

TITLE:

Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.

JOURNAL:

Journal of lipid research None None, Vol 46, pp. 2289-94

ABSTRACT:

1. J Lipid Res. 2005 Oct;46(10):2289-94. Epub 2005 Aug 1. Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats. Asahina M(1), Sato M, Imaizumi K. Author information: (1)Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan. The exogenously hypercholesterolemic (ExHC) rat is an established strain that exhibits a polygenic syndrome of hypercholesterolemia after feeding on a cholesterol-containing diet, and the extent of this differs between male and female rats in the strain. The present study was performed to determine the genetic background of diet-induced hypercholesterolemia in ExHC rats. We used quantitative trait locus (QTL) analyses of the F2 progeny derived from ExHC and Brown-Norway rats. Rats were fed a diet containing 1% cholesterol, and a genome-wide scan was then performed. Significant QTLs for serum total cholesterol levels were revealed on chromosomes 5 and 14 in the vicinity of markers D5Rat95 and D14Rat43, having maximum logarithm of the odds scores of 6.0 and 5.8, respectively. A suggestive QTL for the trait was also detected on chromosome 3 at D3Rat140. In particular, the QTL on chromosome 5 was specific for female rats. These loci were novel QTLs for post-dietary serum total cholesterol levels. In addition, cross-mating analysis in F1 generations suggested that the responsiveness to dietary cholesterol in ExHC rats is partly attributable to X-linked inheritance. Identifying such genetic factors may be useful in predicting the risks associated with diet-induced hypercholesterolemia in humans. PMID: 16061941 [PubMed - indexed for MEDLINE] PUBMED: 16061941
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