DESCRIPTION:

QTL Associated with Copper level. On Chromosome 10 with a LOD score= 4.15, p-value =. From a(n) of BC/CpbuxLEW/OlaHsd

LABEL:

QTL-Hcuc4-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

de Wolf ID, Bonné AC, Fielmich-Bouman XM, van Oost BA, Beynen AC, van Zutphen LF, van Lith HA

TITLE:

Quantitative trait loci influencing hepatic copper in rats.

JOURNAL:

Experimental biology and medicine (Maywood, N.J.) None None, Vol 227, pp. 529-34

ABSTRACT:

1. Exp Biol Med (Maywood). 2002 Jul;227(7):529-34. Quantitative trait loci influencing hepatic copper in rats. de Wolf ID(1), Bonné AC, Fielmich-Bouman XM, van Oost BA, Beynen AC, van Zutphen LF, van Lith HA. Author information: (1)Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, P.O. Box 80.166, NL-3508 TD Utrecht, The Netherlands. wolfid@wish.net Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd x BC/CpbU) F(2)-intercross was genetically analyzed. From each F(2) animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0-15.5% of the genetic variance of liver copper content. PMID: 12094018 [PubMed - indexed for MEDLINE] PUBMED: 12094018
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