DESCRIPTION:

QTL Associated with Body weight. On Chromosome 1 with a LOD score= 3.3, p-value =. From a(n) backcross of

LABEL:

QTL-Bw39-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Kovács P, Klöting I

TITLE:

Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat.

JOURNAL:

Biochemistry and molecular biology international None None, Vol 44, pp. 399-405

ABSTRACT:

1. Biochem Mol Biol Int. 1998 Feb;44(2):399-405. Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat. Kovács P(1), Klöting I. Author information: (1)Department of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany. Quantitative trait loci (QTLs) affecting body weight were investigated in the backcross population derived from diabetic BB/OK and spontaneously hypertensive rat (SHR). The F1 hybrids were backcrossed onto BB/OK rats, and QTL analysis was performed with the resulting backcross population on chromosomes 1, 3, 4, 10, 13 and 18. According to the stringent threshold for a lod score of 3.0, markers on chromosomes 1 and 4 were found to be linked with body weight. The QTL with a peak lod score (3.3) on chromosome 1 for a male population was located within the region flanked by loci Igf2 and D1Mgh12. On chromosome 4, linkage between the body weight and the region around the Npy locus was observed (lod score 3.1). The existence of the QTL on chromosome 4 affecting body weight was confirmed by congenic BB.LL rats, carrying chromosomal region of SHR (D4Mit6-Npy-Spr) on the genetic background of the BB/OK rat. PMID: 9530522 [PubMed - indexed for MEDLINE] PUBMED: 9530522
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