DESCRIPTION:

QTL Associated with Glucose level. On Chromosome 14 with a LOD score= 3.37, p-value =. From a(n) of

LABEL:

QTL-Niddm37-Rat-Chr 14

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Ogino T, Moralejo DH, Zhu M, Toide K, Wei S, Wei K, Yamada T, Mizuno A, Matsumoto K, Shima K

TITLE:

Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat.

JOURNAL:

Genetical research None None, Vol 73, pp. 29-36

ABSTRACT:

1. Genet Res. 1999 Feb;73(1):29-36. Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat. Ogino T(1), Moralejo DH, Zhu M, Toide K, Wei S, Wei K, Yamada T, Mizuno A, Matsumoto K, Shima K. Author information: (1)Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat exhibits sustained hyperglycaemia after partial pancreatectomy, while the normal control rat does not. This difference is thought to be genetically determined and to be caused by impairment of beta-cell regrowth, a possible event involved in the pathogenesis of NIDDM. Our investigation was designed to identify quantitative trait loci (QTL) responsible for post-pancreatectomy hyperglycaemia by performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and Fischer-344 (F344) rats. We have identified three possible QTL on rat chromosomes (Chrs) 3, 14 and 19 that account for a total of approximately 75% of the genetic variance in the F2. For the QTL on Chr 14, the OLETF allele corresponds with increased glucose levels, as expected. Surprisingly, for the QTL on Chr 19, the F344 allele corresponds with increased glucose levels. The Chr 3 QTL exhibits heterosis, heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes. We also found evidence for interaction (epistasis) between the QTL on Chrs 14 and 19. PMID: 10218444 [PubMed - indexed for MEDLINE] PUBMED: 10218444
Find other GeneSets from this publication