DESCRIPTION:

QTL Associated with Body weight. On Chromosome 1 with a LOD score= 9.11, p-value =0.005. From a(n) of

LABEL:

QTL-Bw122-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Watanabe TK, Okuno S, Yamasaki Y, Ono T, Oga K, Mizoguchi-Miyakita A, Miyao H, Suzuki M, Momota H, Goto Y, Shinomiya H, Hishigaki H, Hayashi I, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A

TITLE:

A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats.

JOURNAL:

Clinical and experimental pharmacology & physiology None None, Vol 31, pp. 110-2

ABSTRACT:

1. Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):110-2. A < 1.7 cM interval is responsible for Dmo1 obesity phenotypes in OLETF rats. Watanabe TK(1), Okuno S, Yamasaki Y, Ono T, Oga K, Mizoguchi-Miyakita A, Miyao H, Suzuki M, Momota H, Goto Y, Shinomiya H, Hishigaki H, Hayashi I, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A. Author information: (1)Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan. tkw_watanabe@research.otsuka.co.jp 1. Dmo1 (Diabetes Mellitus OLETF type I) is a major quantitative trait locus for dyslipidaemia, obesity and diabetes phenotypes of male Otsuka Long Evans Tokushima Fatty (OLETF) rats. 2. Our congenic lines, produced by transferring Dmo1 chromosomal segments from the non-diabetic Brown Norway (BN) rat into the OLETF strain, have confirmed the strong, wide-range therapeutic effects of Dmo1 on dyslipidaemia, obesity and diabetes in the fourth (BC4) and fifth (BC5) generations of congenic animals. Analysis of a relatively small number of BC5 rats (n = 71) suggested that the critical Dmo1 interval lies within a < 4.9 cM region between D1Rat461 and D1Rat459. 3. To confirm the assignment of the Dmo1 critical interval, we intercrossed BC5 animals to produce a larger study population (BC5:F1 males; n = 406). For the present study, we used bodyweight at 18 weeks of age as an index of obesity; this phenotype is representative of the closely associated dyslipidaemia and hyperglycaemia phenotypes. 4. Interval mapping assigned logarithm of odds (LOD) peaks at the D1Rat90 marker (LOD = 9.11). One LOD support interval lies within the < 1.7 cM region between D1Rat461 and D1Rat459. 5. This large intercross study confirms that Dmo1 is likely localized within the interval. PMID: 14756694 [PubMed - indexed for MEDLINE] PUBMED: 14756694
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