DESCRIPTION:

QTL Associated with Memory. On Chromosome 17 with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Memor18-Rat-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Herrera VL, Pasion KA, Tan GA, Ruiz-Opazo N

TITLE:

Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.

JOURNAL:

PloS one None None, Vol 8, pp. e58280

ABSTRACT:

1. PLoS One. 2013;8(2):e58280. doi: 10.1371/journal.pone.0058280. Epub 2013 Feb 28. Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp. Herrera VL(1), Pasion KA, Tan GA, Ruiz-Opazo N. Author information: (1)Section of Cardiovascular Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America. A quantitative trait locus (QTL) linked with ability to find a platform in the Morris Water Maze (MWM) was located on chromosome 17 (Nav-5 QTL) using intercross between Dahl S and Dahl R rats. We developed two congenic strains, S.R17A and S.R17B introgressing Dahl R-chromosome 17 segments into Dahl S chromosome 17 region spanning putative Nav-5 QTL. Performance analysis of S.R17A, S.R17B and Dahl S rats in the Morris water maze (MWM) task showed a significantly decreased spatial navigation performance in S.R17B congenic rats when compared with Dahl S controls (P = 0.02). The S.R17A congenic segment did not affect MWM performance delimiting Nav-5 to the chromosome 17 65.02-74.66 Mbp region. Additional fine mapping is necessary to identify the specific gene variant accounting for Nav-5 effect on spatial learning and memory in Dahl rats. PMCID: PMC3585172 PMID: 23469157 [PubMed - indexed for MEDLINE] PUBMED: 23469157
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