DESCRIPTION:

QTL Associated with Glucose level. On Chromosome 12 with a LOD score= 3.42, p-value =. From a(n) intercross of

LABEL:

QTL-Iddm30-Rat-Chr 12

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Colle E, Fuks A, Poussier P, Edouard P, Guttmann RD

TITLE:

Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.

JOURNAL:

Diabetes None None, Vol 41, pp. 1617-23

ABSTRACT:

1. Diabetes. 1992 Dec;41(12):1617-23. Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Colle E(1), Fuks A, Poussier P, Edouard P, Guttmann RD. Author information: (1)McGill University-Montreal Childrens Hospital Research Institute, Québec, Canada. We describe the phenotypic characteristics of animals in the fifth backcross-intercross generation of a breeding program in which the RT1 u haplotype and the phenotypic trait responsible for the T-lymphopenia of BB rats have been transferred to the ACI background. In this generation of animals, 24% were lymphopenic with decreased numbers of PBL expressing CD5, TCR alpha, and RT6. The PBL of the lymphopenic animals had a decreased mitogenic response to ConA. All of the nonlymphopenic animals were homozygous for RT6.2. Phenotypic analysis of intestinal IEL revealed that this was also the case for the lymphopenic animals. Moreover, IEL of the lymphopenic animals exhibited a pattern of staining (increased numbers of TCR alpha beta+CD4+CD8+ and decreased numbers of TCR alpha beta+CD4-CD8+) similar to that of BB DP animals. The ACI.1U(BB)-lymphopenic animals, although having two of the genetic traits associated with the expression of spontaneous diabetes mellitus, uniformly fail to develop diabetes. Breeding studies in which these animals were crossed with BB and hBB rats suggest that other genes are necessary for development of overt diabetes. PMID: 1446803 [PubMed - indexed for MEDLINE] PUBMED: 1446803
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