1. Pathol Int. 1997 Jul;47(7):436-41.
Genetic mapping of genes regulating the thymus size in back-cross rats between
the laboratory BUF/Mna strain and the MITE strain derived from the wild rat,
Rattus norvegicus.
Sharma N(1), Ohyabu A, Murakumo Y, Takahashi M, Saito M, Amo H, Murayama S, Ohno
K, Oda S, Matsuyama M.
Author information:
(1)Department of Pathology, Nagoya University School of Medicine, Japan.
The thymoma prone BUF/Mna (B) rat is a useful model for studying the genes
responsible for thymus enlargement during the stage of young growth. Among the
strains of rats, B rats have the largest thymuses at all stages of life. A locus,
Ten-1, which contributes to thymus enlargement in back-cross (BC) rats between
the B and WKY/NCrj (W) strains, was mapped on chromosome 1. To determine the
precise location of the locus, ¿B x(B x MITE)F1¿ BC rats were generated by
crossing the B strain with the inbred MITE (M) strain, which was established from
captured, Japanese wild rats, and were examined by linkage study using polymerase
chain reaction with 67 microsatellite markers. Linkages with thymus enlargement
were found in genotypes of seven markers, BSIS, LSN, MYL2, IGF2, PBPC2, D1Mgh11,
and D1MIt6, by chi2-test and Student's t-test, which confirmed the presence of
the genetic locus associated with thymus enlargement, Ten-1, in this region.
Paradoxically, a suppressive locus, Tsu-1, to thymus enlargement was also found
on chromosome 3, showing linkages of phenotype of the small thymus with genotypes
of SCN2A, CAT, D3MIt16, and D3MIt13. By analyses of MAPMAKER/EXP and
MAPMAKER/QTL, Ten-1 was mapped at 4.6 cM proximal from IGF2 locus on chromosome 1
and Tsu-1 at 4.0 cM proximal from CAT locus on chromosome 3, respectively.
PMID: 9234381 [PubMed - indexed for MEDLINE]
PUBMED: 9234381
Find other GeneSets from this publication
GeneWeaver