DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 1 with a LOD score= 4.64, p-value =4.87E-06. From a(n) backcross of F344/NHsdxBN/SsNHsd

LABEL:

QTL-Stl31-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Yamasaki Y, Watanabe TK, Okuno S, Ono T, Oga K, Mizoguchi-Miyakita A, Goto Y, Shinomiya H, Momota H, Miyao H, Hayashi I, Asai T, Suzuki M, Harada Y, Hishigaki H, Wakitani S, Takagi T, Nakamura Y, Tanigami A

TITLE:

Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats.

JOURNAL:

Clinical and experimental pharmacology & physiology None None, Vol 27, pp. 881-6

ABSTRACT:

1. Clin Exp Pharmacol Physiol. 2000 Nov;27(11):881-6. Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats. Yamasaki Y(1), Watanabe TK, Okuno S, Ono T, Oga K, Mizoguchi-Miyakita A, Goto Y, Shinomiya H, Momota H, Miyao H, Hayashi I, Asai T, Suzuki M, Harada Y, Hishigaki H, Wakitani S, Takagi T, Nakamura Y, Tanigami A. Author information: (1)Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan. 1. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a model of type II diabetes with accompanying dyslipidaemia and obesity. 2. To define chromosomal intervals associated with obesity (abdominal fat weight and plasma leptin levels), dyslipidaemia (plasma triglyceride, cholesterol and free fatty acids) and hyperglycaemia (plasma glucose levels), we have performed genome-wide quantitative traits loci (QTL) analyses of 115 male OLETF x (OLETF x Fischer 344) backcross animals at 16 weeks of age. 3. The Diabetes Mellitus OLETF type I (Dmo1) locus on rat chromosome 1 showed statistically significant involvement in elevations of plasma levels of triglycerides (P = 4.87 x 10(-6) at D1Rat90) and total cholesterol (P = 1.16 x 10(-5) at D1Rat306). 4. No other loci produced significant linkage to these observed phenotypes. 5. These analyses have confirmed the importance of Dmo1 in lipid homeostasis at younger ages as well as during overt diabetes, which appears later. Thus, alterations at the Dmo1 locus are a major risk factor for pathogenesis in the strain, a finding that agrees with physiological studies that indicate a role for dyslipidaemia in the type II diabetic syndrome of OLETF rats. PMID: 11071303 [PubMed - indexed for MEDLINE] PUBMED: 11071303
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