DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 1 with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Bp267-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Iwai N, Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H

TITLE:

Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat.

JOURNAL:

Hypertension None None, Vol 45, pp. 947-53

ABSTRACT:

1. Hypertension. 2005 May;45(5):947-53. Epub 2005 Apr 4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N(1), Yasui N, Naraba H, Tago N, Yamawaki H, Sumiya H. Author information: (1)Research Institute, National Cardiovascular Center, Suita, Osaka, Japan. iwai@ri.ncvc.go.jp A genome-wide quantitative trait loci analysis for blood pressure was performed using 107 male F2 rats derived from Dahl salt-sensitive and Lewis rats. Blood pressure was assessed by telemetry, and >400 microsatellite markers were used for genotyping. Two major quantitative trait loci for blood pressure were identified at chromosome 1 and chromosome 10. The expression levels of 366 transcripts around the chromosome 1 quantitative trait loci were assessed by RT-PCR, and we found that the Klk1 (kallikrein 1) and Ngfg (nerve growth factor gamma) mRNA levels were significantly reduced in the kidneys of Dahl salt-sensitive rats compared with those in Lewis rats. The expression levels of kallikrein 1 protein were also suppressed in Dahl salt-sensitive rats compared with those in Lewis rats. Because the kallikrein-kinin system has been shown to be involved in renal function, including salt homeostasis, it is likely that the reduced expression of Klk1 contributes to salt-sensitive hypertension in Dahl salt-sensitive rats. PMID: 15809361 [PubMed - indexed for MEDLINE] PUBMED: 15809361
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