DESCRIPTION:

QTL Associated with blood leptin amount. On Chromosome 5 with a LOD score= 5.2, p-value =0.001. From a(n) of QTL Associated with Body weight. On Chromosome 4 with a LOD score= 7.3, p-value =. From a(n) intercross;<b>measurement method</b>: 45 days old rats were infected in the whiskers area with 2X10⁶ PFU of HSV-1 and change in body weight from the day of infection to 5 days post-infection (d0-d5)determined of

LABEL:

QTL-Bw143-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Abdelmagid N, Bereczky-Veress B, Guerreiro-Cacais AO, Bergman P, Luhr KM, Bergström T, Sköldenberg B, Piehl F, Olsson T, Diez M

TITLE:

The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.

JOURNAL:

PLoS pathogens None None, Vol 8, pp. e1002753

ABSTRACT:

1. PLoS Pathog. 2012;8(6):e1002753. doi: 10.1371/journal.ppat.1002753. Epub 2012 Jun 28. The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. Abdelmagid N(1), Bereczky-Veress B, Guerreiro-Cacais AO, Bergman P, Luhr KM, Bergström T, Sköldenberg B, Piehl F, Olsson T, Diez M. Author information: (1)Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. nada.abdelmagid@ki.se Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development. PMCID: PMC3386237 PMID: 22761571 [PubMed - indexed for MEDLINE] PUBMED: 22761571
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