DESCRIPTION:

QTL Associated with Glucose level. On Chromosome 17 with a LOD score= 2, p-value =. From a(n) intercross of

LABEL:

QTL-Gluco49-Rat-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Solberg Woods LC, Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE

TITLE:

Identification of genetic loci involved in diabetes using a rat model of depression.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 20, pp. 486-97

ABSTRACT:

1. Mamm Genome. 2009 Aug;20(8):486-97. doi: 10.1007/s00335-009-9211-8. Epub 2009 Aug 22. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC(1), Ahmadiyeh N, Baum A, Shimomura K, Li Q, Steiner DF, Turek FW, Takahashi JS, Churchill GA, Redei EE. Author information: (1)Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. lsolberg@mcw.edu While diabetic patients often present with comorbid depression, the underlying mechanisms linking diabetes and depression are unknown. The Wistar Kyoto (WKY) rat is a well-known animal model of depression and stress hyperreactivity. In addition, the WKY rat is glucose intolerant and likely harbors diabetes susceptibility alleles. We conducted a quantitative trait loci (QTL) analysis in the segregating F(2) population of a WKY x Fischer 344 (F344) intercross. We previously published QTL analyses for depressive behavior and hypothalamic-pituitary-adrenal (HPA) activity in this cross. In this study we report results from the QTL analysis for multiple metabolic phenotypes, including fasting glucose, post-restraint stress glucose, postprandial glucose and insulin, and body weight. We identified multiple QTLs for each trait and many of the QTLs overlap with those previously identified using inbred models of type 2 diabetes (T2D). Significant correlations were found between metabolic traits and HPA axis measures, as well as forced swim test behavior. Several metabolic loci overlap with loci previously identified for HPA activity and forced swim behavior in this F(2) intercross, suggesting that the genetic mechanisms underlying these traits may be similar. These results indicate that WKY rats harbor diabetes susceptibility alleles and suggest that this strain may be useful for dissecting the underlying genetic mechanisms linking diabetes, HPA activity, and depression. PMCID: PMC2775460 PMID: 19697080 [PubMed - indexed for MEDLINE] PUBMED: 19697080
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