DESCRIPTION:

QTL Associated with Body weight. On Chromosome 1 with a LOD score= 4, p-value =. From a(n) intercross of QTL Associated with Body weight. On Chromosome 5 with a LOD score= 4.47, p-value =. From a(n) intercross of

LABEL:

QTL-Bw84-Rat-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Kovács P, van den Brandt J, Klöting I

TITLE:

Genetic dissection of the syndrome X in the rat.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 269, pp. 660-5

ABSTRACT:

1. Biochem Biophys Res Commun. 2000 Mar 24;269(3):660-5. Genetic dissection of the syndrome X in the rat. Kovács P(1), van den Brandt J, Klöting I. Author information: (1)Department of Laboratory Animal Science, University Greifswald, Karlsburg, 17495, Germany. In 1988, Reaven used the term syndrome X to describe a relation between several disorders including hypertension, dyslipidemia, impaired glucose tolerance, obesity, and coronary heart disease. Despite a number of studies dealing with syndrome X, its genetic basis remains poorly understood. Regarding the complexity of this syndrome, it is important to use animal models developing the traits of the disease. Here we show a genetic dissection of syndrome X in the WOKW rat, an animal model of genetically determined syndrome X. We found a major quantitative trait locus (QTL) for glucose metabolism on chromosome 3 and further QTLs influencing obesity and body weight on chromosomes 1 and 5. Genetic determinants of dyslipidemia were mapped to chromosomes 4 and 17. In addition, suggestive linkage for serum insulin was found on chromosome 1 to the region previously shown to be associated with type-1 diabetes mellitus. This is the first study demonstrating independent genetic factors influencing traits of the syndrome X in the rat as well as a possible genetic relationships between syndrome X and diabetes mellitus. Moreover, regarding the close similarities between WOKW rat and human syndrome X, the study could help in a search of genetic factors involved in this complex metabolic disorder in human. Copyright 2000 Academic Press. PMID: 10720472 [PubMed - indexed for MEDLINE] PUBMED: 10720472
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