1. Genomics. 1999 Dec 15;62(3):350-5.
Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF
backcross rats.
Okuno S(1), Watanabe TK, Ono T, Yamasaki Y, Goto Y, Miyao H, Asai T, Kanemoto N,
Oga K, Mizoguchi-Miyakita A, Takagi T, Takahashi E, Nakamura Y, Tanigami A.
Author information:
(1)Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10
Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan.
Altered lipid metabolism is closely associated with diabetes in humans, although
predisposing genetic factors that affect hyperlipidemia have not yet been
clarified. Our previously established OLETF strain is an obese rat model of type
II diabetes, exhibiting hypertriglycemia as well as hyperinsulinemia,
hyperglycemia, insulin resistance, and abundant abdominal fat. To identify
genetic factors responsible for dyslipidemic phenotypes in OLETF rats, we
performed a whole-genome scan using 293 male (OLETF x BN) x OLETF backcross rats.
Our analysis identified two significant quantitative trait loci (QTLs), on rat
chromosomes 1 and 8, that are related to fasting triglyceride levels. The
chromosome 1 QTL colocalized with Dmo1 (diabetes mellitus, OLETF type 1), a locus
previously shown to associate strongly with both fat levels and body weight. The
other significant QTL localizes to the chromosome 8 marker D8Mit2, in a region
where several apo-lipoprotein genes are clustered.
Copyright 1999 Academic Press.
PMID: 10644432 [PubMed - indexed for MEDLINE]
PUBMED: 10644432
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