DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 10 with a LOD score= , p-value =0.04. From a(n) of

LABEL:

QTL-Bp71-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Deng AY, Dutil J, Sivo Z

TITLE:

Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 12, pp. 612-6

ABSTRACT:

1. Mamm Genome. 2001 Aug;12(8):612-6. Utilization of marker-assisted congenics to map two blood pressure quantitative trait loci in Dahl rats. Deng AY(1), Dutil J, Sivo Z. Author information: (1)Research Centre-CHUM, Hôtel Dieu, 7-132 Pavillon Jeanne Mance, 3840 rue St. Urbain, Montréal, Québec, H2W 1T8, Canada. alan.deng@umontreal.ca A broad Chromosome (Chr) 10 region of the Dahl salt-sensitive (S) rat was shown by linkage and the use of congenic strains to contain a blood pressure (BP) quantitative trait locus (QTL). To further narrow down the region harboring the QTL, four congenic strains carrying smaller segments were made by replacing various segments of the S rats with the homologous segments of the Lewis (LEW) rats. The construction of these congenic strains was facilitated by a genome-wide marker screening. One congenic strain, assigned as S.L4, showed a BP-lowering effect, and the region harboring a BP QTL, designated QTL1, is localized to a segment of about 15 cM. Two other strains, assigned as S.L2 and S.L5, contained an overlapping segment, and both showed a BP-lowering effect. In contrast, the fourth congenic strain, assigned as S.L1, contained a smaller and shared fragment with S.L2 and S.L5, but it did not have a BP-lowering effect. Deducing from the segment in common in S.L2 and S.L5, and not shared between S.L1 and both congenic strains S.L2 and S.L5, the region harboring a QTL, designated as QTL2, was narrowed to about 12 cM. The current work showed the general applicability of the 'speed congenic' approach to map and fine-map BP QTL. PMID: 11471055 [PubMed - indexed for MEDLINE] PUBMED: 11471055
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