1. Immunogenetics. 1999 Aug;49(9):787-91.
Identification of a new quantitative trait locus on chromosome 7 controlling
disease severity of collagen-induced arthritis in rats.
Dracheva SV(1), Remmers EF, Gulko PS, Kawahito Y, Longman RE, Reese VR, Cannon
GW, Griffiths MM, Wilder RL.
Author information:
(1)Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National
Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes
Of Health, Bldg. 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892,
USA.
Autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, and multiple
sclerosis, are regulated by multiple genes. Major histocompatibility complex
(MHC) genes have the strongest effects, but non-MHC genes also contribute to
disease susceptibility/severity. In this paper, we describe a new non-MHC
quantitative trait locus, Cia8, on rat Chromosome (Chr) 7 that controls
collagen-induced arthritis severity in F2 progeny of DA and F344 inbred rats, and
present an updated localization of Cia4 on the same chromosome. We also describe
the location of mouse and human genes, orthologous to the genes in the genomic
intervals containing Cia4 and Cia8, and provide evidence that the segment of rat
Chr 7 containing Cia4 and Cia8 is homologous to segments of mouse Chr 10 and 15
and human Chr 8, 12, and 19.
PMID: 10398805 [PubMed - indexed for MEDLINE]
PUBMED: 10398805
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